PNKP

PNKP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BRF, 2W3O
Identifiers
Aliases	PNKP, EIEE10, MCSZ, PNK, AOA4, polynucleotide kinase 3'-phosphatase, CMT2B2
External IDs	OMIM: 605610; MGI: 1891698; HomoloGene: 5247; GeneCards: PNKP; OMA:PNKP - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,878,351 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,512,416 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; granulocyte; ; right adrenal cortex; ; anterior pituitary; ; right lobe of thyroid gland; ; left adrenal gland; ; left adrenal cortex; ; left lobe of thyroid gland; ; right ovary; ; apex of heart;
	Top expressed in
	granulocyte; ; spermatocyte; ; muscle of thigh; ; ventricular zone; ; bone marrow; ; right kidney; ; thymus; ; lip; ; yolk sac; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; polydeoxyribonucleotide 5'-hydroxyl-kinase activity; kinase activity; damaged DNA binding; protein binding; catalytic activity; purine nucleotide binding; endonuclease activity; double-stranded DNA binding; hydrolase activity; ATP binding; polynucleotide 3'-phosphatase activity; nucleoside monophosphate kinase activity; polynucleotide kinase activity;
Cellular component	membrane; nucleoplasm; nucleolus; nucleus; mitochondrion;
Biological process	DNA-dependent DNA replication; nucleotide-excision repair, DNA damage removal; positive regulation of telomere capping; phosphorylation; positive regulation of telomere maintenance via telomerase; response to oxidative stress; cellular response to DNA damage stimulus; nucleotide phosphorylation; positive regulation of telomerase activity; response to radiation; metabolism; dephosphorylation; polynucleotide 3' dephosphorylation; DNA repair; nucleic acid phosphodiester bond hydrolysis; negative regulation of protein ADP-ribosylation; nucleoside monophosphate phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	11284
	59047
	ENSG00000039650
	ENSMUSG00000002963
	Q96T60
	Q9JLV6
	NM_007254
	NM_001290764; NM_001290766; NM_001290767; NM_021549
	NP_009185
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Bifunctional polynucleotide phosphatase/kinase is an enzyme that in humans is encoded by the PNKP gene. A detailed structural study of the crystallized mouse protein examined both the 5´-polynucleotide kinase and 3’-polynucleotide phosphatase activities. Additional features of the peptide sequence include a forkhead association (FHA) domain, ATP binding site and nuclear and mitochondrial localization sequences.