PITX3

PITX3
Identifiers
Aliases	PITX3, ASMD, ASOD, CTPP4, CTRCT11, PTX3, paired like homeodomain 3, ASGD1
External IDs	OMIM: 602669; MGI: 1100498; HomoloGene: 3689; GeneCards: PITX3; OMA:PITX3 - orthologs
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	46,136,765 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; skeletal muscle tissue; ; ventricle of the heart; ; left ventricle; ; Mesencephalon; ; substantia nigra; ; face; ; sensory nervous system; ; sensory organ; ; kidney;
	Top expressed in
	lens; ; muscle of thigh; ; embryo; ; lip; ; female urethra; ; male urethra; ; lens placode; ; temporal muscle; ; embryo; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; soma;
Biological process	animal organ morphogenesis; positive regulation of transcription, DNA-templated; multicellular organism development; dopaminergic neuron differentiation; regulation of gene expression; neuron development; lens development in camera-type eye; regulation of transcription, DNA-templated; lens fiber cell differentiation; lens morphogenesis in camera-type eye; transcription by RNA polymerase II; locomotory behavior; midbrain development; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; ageing; negative regulation of gliogenesis; response to immobilization stress; response to cocaine; response to morphine; positive regulation of neuron apoptotic process; negative regulation of neurogenesis; response to methamphetamine hydrochloride; positive regulation of cell proliferation in midbrain; cellular response to glial cell derived neurotrophic factor; anatomical structure morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5309
	18742
	n/a
	ENSMUSG00000025229
	O75364
	O35160
	NM_005029
	NM_008852
	NP_005020
	NP_032878
	Wikidata
View/Edit Human	View/Edit Mouse

Pituitary homeobox 3 is a protein that in humans is encoded by the PITX3 gene.