PIP4K2B

PIP4K2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BO1, 3WZZ, 3X01, 3X02, 3X03, 3X04, 3X05, 3X06, 3X07, 3X08, 3X09, 3X0A, 3X0B, 3X0C
Identifiers
Aliases	PIP4K2B, PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
External IDs	OMIM: 603261; MGI: 1934234; HomoloGene: 2634; GeneCards: PIP4K2B; OMA:PIP4K2B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	38,800,126 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,635,530 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Brodmann area 9; ; right frontal lobe; ; anterior cingulate cortex; ; prefrontal cortex; ; ventricular zone; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; muscle of leg; ; muscle of thigh;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; muscle of thigh; ; internal carotid artery; ; superior frontal gyrus; ; external carotid artery; ; hand; ; gastrocnemius muscle; ; foot; ; facial motor nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; 1-phosphatidylinositol-4-phosphate 5-kinase activity; kinase activity; phosphatidylinositol phosphate kinase activity; protein binding; ATP binding; 1-phosphatidylinositol-3-phosphate 4-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; protein homodimerization activity;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum membrane; membrane; plasma membrane; autophagosome; endoplasmic reticulum; nucleus; nucleoplasm;
Biological process	phosphatidylinositol metabolic process; positive regulation of autophagosome assembly; phosphorylation; cell surface receptor signaling pathway; regulation of autophagy; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphate biosynthetic process; regulation of phosphatidylinositol 3-kinase signaling; phospholipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8396
	108083
	ENSG00000277292; ENSG00000276293
	ENSMUSG00000018547
	P78356
	Q80XI4
	NM_003559; NM_138687
	NM_054051
	NP_003550
	NP_473392
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol 4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.