PIGQ

PIGQ
Identifiers
Aliases	PIGQ, GPI1, c407A10.1, phosphatidylinositol glycan anchor biosynthesis class Q, EIEE77, DEE77, MCAHS4, GPIBD19
External IDs	OMIM: 605754; MGI: 1333114; HomoloGene: 31228; GeneCards: PIGQ; OMA:PIGQ - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	584,109 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	26,163,910 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; right uterine tube; ; left lobe of thyroid gland; ; right testis; ; anterior pituitary; ; left testis; ; right frontal lobe; ; body of pancreas; ; right hemisphere of cerebellum; ; right adrenal cortex;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; motor neuron; ; substantia nigra; ; fossa; ; ciliary body; ; endocardial cushion; ; barrel cortex; ; medullary collecting duct; ; ascending aorta; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; phosphatidylinositol N-acetylglucosaminyltransferase activity; glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; membrane;
Biological process	GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9091
	14755
	ENSG00000007541
	ENSMUSG00000025728
	Q9BRB3
	Q9QYT7
	NM_148920; NM_004204
	NM_001291025; NM_011822; NM_001357592
	NP_004195; NP_683721
	NP_001277954; NP_035952; NP_001344521
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.

This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).