PEX1

PEX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WLF
Identifiers
Aliases	PEX1, PBD1A, PBD1B, ZWS, ZWS1, HMLR1, peroxisomal biogenesis factor 1
External IDs	OMIM: 602136; MGI: 1918632; HomoloGene: 27006; GeneCards: PEX1; OMA:PEX1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	92,528,520 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	3,687,232 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; body of pancreas; ; gastric mucosa; ; skin of leg; ; right hemisphere of cerebellum; ; skin of abdomen; ; rectum; ; C1 segment; ; left lobe of thyroid gland; ; tibial nerve;
	Top expressed in
	zygote; ; secondary oocyte; ; neural layer of retina; ; hand; ; left lobe of liver; ; primary oocyte; ; tail of embryo; ; epithelium of small intestine; ; superior frontal gyrus; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; nucleotide binding; protein C-terminus binding; protein binding; ATP binding; ATPase activity;
Cellular component	cytoplasm; cytosol; peroxisomal membrane; peroxisome; extracellular exosome; membrane;
Biological process	protein targeting to peroxisome; protein transport; microtubule-based peroxisome localization; peroxisome organization; protein import into peroxisome matrix; transport;
	Sources:Amigo / QuickGO
Orthologs
	5189
	71382
	ENSG00000127980
	ENSMUSG00000005907
	O43933
	Q5BL07
	NM_000466; NM_001282677; NM_001282678
	NM_001293806; NM_027777; NM_177211
	NP_000457; NP_001269606; NP_001269607
	NP_001280735; NP_082053
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisome biogenesis factor 1, also known as PEX1, is a protein which in humans is encoded by the PEX1 gene.

This gene encodes a member of the AAA protein family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome.