PDXK

PDXK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AJP, 2F7K, 2YXT, 2YXU, 3FHX, 3FHY, 3KEU, 4EN4, 4EOH
Identifiers
Aliases	PDXK, C21orf124, C21orf97, HEL-S-1a, PKH, PNK, PRED79, pyridoxal (pyridoxine, vitamin B6) kinase, pyridoxal kinase, HMSN6C
External IDs	OMIM: 179020; MGI: 1351869; HomoloGene: 2731; GeneCards: PDXK; OMA:PDXK - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	43,762,307 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	78,300,809 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; sperm; ; renal medulla; ; dorsal motor nucleus of vagus nerve; ; anterior pituitary; ; Brodmann area 23; ; right frontal lobe; ; Brodmann area 46; ; nucleus accumbens;
	Top expressed in
	central gray substance of midbrain; ; vestibular membrane of cochlear duct; ; entorhinal cortex; ; perirhinal cortex; ; nucleus accumbens; ; motor neuron; ; nucleus of stria terminalis; ; superior colliculus; ; morula; ; morula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein homodimerization activity; pyridoxal kinase activity; zinc ion binding; potassium ion binding; sodium ion binding; metal ion binding; kinase activity; lithium ion binding; pyridoxal phosphate binding; ATP binding; magnesium ion binding;
Cellular component	cytosol; extracellular exosome; nucleus; extracellular region; cytoplasm; secretory granule lumen; specific granule lumen; nucleoplasm;
Biological process	pyridoxal phosphate biosynthetic process; phosphorylation; pyridoxal 5'-phosphate salvage; cell population proliferation; neutrophil degranulation; vitamin B6 metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8566
	216134
	ENSG00000160209
	ENSMUSG00000032788
	O00764
	Q8K183
	NM_003681; NM_021941; NM_001331030
	NM_172134
	NP_001317959; NP_003672
	NP_742146
	Wikidata
View/Edit Human	View/Edit Mouse

Pyridoxal kinase is an enzyme that in humans is encoded by the PDXK gene.

The protein encoded by this gene phosphorylates vitamin B₆, a step required for the conversion of vitamin B₆ to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.