PARL

PARL
Identifiers
Aliases	PARL, PSARL, PSARL1, PSENIP2, RHBDS1, PRO2207, presenilin associated rhomboid like
External IDs	OMIM: 607858; MGI: 1277152; HomoloGene: 10239; GeneCards: PARL; OMA:PARL - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	183,884,933 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	20,121,137 bp
RNA expression pattern
	Top expressed in
	monocyte; ; olfactory zone of nasal mucosa; ; thymus; ; apex of heart; ; muscle layer of sigmoid colon; ; body of pancreas; ; gastric mucosa; ; putamen; ; mucosa of transverse colon; ; tibial arteries;
	Top expressed in
	primary oocyte; ; embryonic cell; ; zygote; ; secondary oocyte; ; yolk sac; ; epiblast; ; otic vesicle; ; proximal tubule; ; epidermis; ; zone of skin;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; protein binding; hydrolase activity; serine-type endopeptidase activity; endopeptidase activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; membrane; nucleus; mitochondrion;
Biological process	regulation of reactive oxygen species metabolic process; regulation of protein targeting to mitochondrion; regulation of proteolysis; proteolysis; membrane protein proteolysis; regulation of mitochondrion organization; mitochondrial calcium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	55486
	381038
	ENSG00000175193
	ENSMUSG00000033918
	Q9H300
	Q5XJY4
NM_001037639; NM_001037640; NM_018622; NM_001324436; NM_001324437;
	NM_001324438
	NM_001005767
	NP_001032728; NP_001311365; NP_001311366; NP_001311367; NP_061092
	NP_001005767
	Wikidata
View/Edit Human	View/Edit Mouse

Presenilins-associated rhomboid-like protein, mitochondrial (PSARL), also known as PINK1/PGAM5-associated rhomboid-like protease (PARL), is an inner mitochondrial membrane protein that in humans is encoded by the PARL gene on chromosome 3. It is a member of the rhomboid family of intramembrane serine proteases. This protein is involved in signal transduction and apoptosis, as well as neurodegenerative diseases and type 2 diabetes.