PACRG

PACRG
Identifiers
Aliases	PACRG, GLUP, HAK005771, PARK2CRG, PARK2 co-regulated, PARK2 coregulated, parkin coregulated, PACRG2.1
External IDs	OMIM: 608427; MGI: 1916560; HomoloGene: 16212; GeneCards: PACRG; OMA:PACRG - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	163,315,500 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	11,059,198 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; olfactory zone of nasal mucosa; ; left testis; ; right testis; ; sperm; ; anterior pituitary; ; gonad; ; mucosa of paranasal sinus; ; apex of heart;
	Top expressed in
	seminiferous tubule; ; facial motor nucleus; ; spermatid; ; olfactory epithelium; ; lumbar subsegment of spinal cord; ; spermatocyte; ; choroid plexus of fourth ventricle; ; secondary oocyte; ; anterior horn of spinal cord; ; Epithelium of choroid plexus;
	More reference expression data
	n/a
Gene ontology
Molecular function	Hsp70 protein binding; Hsp90 protein binding; actin binding; alpha-tubulin binding; chaperone binding; G protein-coupled receptor binding; heat shock protein binding; ubiquitin protein ligase binding; beta-tubulin binding;
Cellular component	cell body; vesicle; cytosol; neuron projection; sperm midpiece; cilium; mitochondrion; nucleus;
Biological process	negative regulation of cell death; Unfolded Protein Response; spermatid development;
	Sources:Amigo / QuickGO
Orthologs
	135138
	69310
	ENSG00000112530
	ENSMUSG00000037196
	Q96M98
	Q9DAK2
	NM_001080378; NM_001080379; NM_152410
	NM_027032
	NP_001073847; NP_001073848; NP_689623
	NP_081308
	Wikidata
View/Edit Human	View/Edit Mouse

Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene.

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.