Ohio State Route 450

State Route 450 (SR 450) is a short east–west state highway in southwestern Ohio, specifically near the eastern Cincinnati suburb of Milford. The western terminus of State Route 450 is at the Milford city limits, just west of a partial cloverleaf interchange with Interstate 275, with the road continuing into Milford known as Milford Parkway, which passes by the River's Edge Shopping Center and several distribution-oriented businesses prior to meeting U.S. Route 50 at the intersection marking the western terminus of State Route 131. State Route 450's eastern terminus is at U.S. Route 50, less than 1 mile (1.6 km) east of Interstate 275.

State Route 450's primary function is as a connector route between Interstate 275 and U.S. Route 50, as there is no direct access between the two routes at the point where U.S. Route 50 passes underneath Interstate 275.