OMA1

OMA1
Identifiers
Aliases	OMA1, 2010001O09Rik, DAB1, MPRP-1, YKR087C, ZMPpeptidase, OMA1 zinc metallopeptidase, MPRP1
External IDs	OMIM: 617081; MGI: 1914263; HomoloGene: 12070; GeneCards: OMA1; OMA:OMA1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	58,546,802 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	103,229,065 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; Achilles tendon; ; mucosa of paranasal sinus; ; muscle of thigh; ; bone marrow cells; ; testicle; ; right uterine tube; ; epithelium of colon; ; corpus callosum; ; gonad;
	Top expressed in
	interventricular septum; ; zygote; ; transitional epithelium of urinary bladder; ; right ventricle; ; myocardium of ventricle; ; sternocleidomastoid muscle; ; digastric muscle; ; temporal muscle; ; epithelium of stomach; ; vastus lateralis muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity;
Cellular component	membrane; integral component of membrane; mitochondrial membranes; mitochondrion; mitochondrial inner membrane;
Biological process	mitochondrial protein processing; energy homeostasis; response to stress; mitochondrion organization; cristae formation; protein quality control for misfolded or incompletely synthesized proteins; negative regulation of mitochondrial fusion; proteolysis; lipid metabolism; glucose metabolic process; diet induced thermogenesis; regulation of apoptotic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	115209
	67013
	ENSG00000162600
	ENSMUSG00000035069
	Q96E52
	Q9D8H7
	NM_145243
	NM_025909
	NP_660286
	NP_080185
	Wikidata
View/Edit Human	View/Edit Mouse

Metalloendopeptidase OMA1, mitochondrial is an enzyme that in humans is encoded by the OMA1 gene. OMA1 is a Zn²⁺-dependent metalloendopeptidase in the inner membrane of mitochondria. The OMA1 acronym was derived from overlapping proteolytic activity with m-AAA protease 1.

The OMA1 protease acts at the intersection of a mitochondrial quality control system and energy metabolism, whereby its activation correlates with outer membrane permeabilization and cytochrome c release in the context of apoptosis.

Mammalian OMA1 can cleave the inner-membrane shaping protein OPA1 and the signaling peptide DELE1 in a context-dependent manner.