Methylated-DNA-protein-cysteine methyltransferase

MGMT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EH6, 1EH7, 1EH8, 1QNT, 1T38, 1T39, 1YFH
Identifiers
Aliases	MGMT, Mgmt, AGT, AI267024, Agat, O-6-methylguanine-DNA methyltransferase
External IDs	OMIM: 156569; MGI: 96977; HomoloGene: 31089; GeneCards: MGMT; OMA:MGMT - orthologs
EC number	2.1.1.63
Gene location (Human)
Chr.	Chromosome 10 (human)
End	129,770,983 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	136,731,995 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; muscle of thigh; ; right uterine tube; ; olfactory zone of nasal mucosa; ; body of stomach; ; tendon of biceps brachii; ; body of pancreas; ; apex of heart; ; gastric mucosa; ; gallbladder;
	Top expressed in
	proximal tubule; ; embryo; ; right kidney; ; liver; ; yolk sac; ; primary oocyte; ; left lobe of liver; ; atrioventricular valve; ; stomach; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; DNA binding; calcium ion binding; DNA-methyltransferase activity; metal ion binding; catalytic activity; methylated-DNA-[protein-cysteine S-methyltransferase activity];
Cellular component	membrane; nucleoplasm; nucleus;
Biological process	response to organic cyclic compound; positive regulation of DNA repair; cellular response to organic cyclic compound; negative regulation of cell death; regulation of cysteine-type endopeptidase activity involved in apoptotic process; mammary gland epithelial cell differentiation; cellular response to DNA damage stimulus; DNA ligation; methylation; cellular response to ionizing radiation; cellular response to oxidative stress; response to folic acid; response to ethanol; response to toxic substance; positive regulation of double-strand break repair; DNA repair; DNA methylation; negative regulation of apoptotic process; DNA dealkylation involved in DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	4255
	17314
	ENSG00000170430
	ENSMUSG00000054612
	P16455
	P26187
	NM_002412
	NM_008598; NM_001377037
	NP_002403
	NP_032624; NP_001363966
	Wikidata
View/Edit Human	View/Edit Mouse

Methylated-DNA--protein-cysteine methyltransferase (MGMT), also known as O⁶-alkylguanine DNA alkyltransferase AGT, is a protein that in humans is encoded by the MGMT gene. MGMT is crucial for genome stability. It repairs the naturally occurring mutagenic DNA lesion O⁶-methylguanine back to guanine and prevents mismatch and errors during DNA replication and transcription. Accordingly, loss of MGMT increases the carcinogenic risk in mice after exposure to alkylating agents. The two bacterial isozymes are Ada and Ogt.