Neuropeptide Y receptor
| neuropeptide Y receptor Y1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | NPY1R | ||||||
| Alt. symbols | NPYR | ||||||
| NCBI gene | 4886 | ||||||
| HGNC | 7956 | ||||||
| OMIM | 162641 | ||||||
| RefSeq | NM_000909 | ||||||
| UniProt | P25929 | ||||||
| Other data | |||||||
| Locus | Chr. 4 q31.3-q32 | ||||||
| |||||||
| neuropeptide Y receptor Y2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | NPY2R | ||||||
| NCBI gene | 4887 | ||||||
| HGNC | 7957 | ||||||
| OMIM | 162642 | ||||||
| RefSeq | NM_000910 | ||||||
| UniProt | P49146 | ||||||
| Other data | |||||||
| Locus | Chr. 4 q31 | ||||||
| |||||||
| pancreatic polypeptide receptor 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PPYR1 | ||||||
| Alt. symbols | NPY4R, Y4, PP1 | ||||||
| NCBI gene | 5540 | ||||||
| HGNC | 9329 | ||||||
| OMIM | 601790 | ||||||
| RefSeq | NM_005972 | ||||||
| UniProt | P50391 | ||||||
| Other data | |||||||
| Locus | Chr. 10 q11.2 | ||||||
| |||||||
| neuropeptide Y receptor Y5 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | NPY5R | ||||||
| NCBI gene | 4889 | ||||||
| HGNC | 7958 | ||||||
| OMIM | 602001 | ||||||
| RefSeq | NM_006174 | ||||||
| UniProt | Q15761 | ||||||
| Other data | |||||||
| Locus | Chr. 4 q31-q32 | ||||||
| |||||||
Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.
Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex. The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP.
Only the crystal structure of Y1 in complex with two antagonist is available.