Neuroblastoma RAS viral oncogene homolog

NRAS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CON, 2N9C
Identifiers
Aliases	NRAS, ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, Neuroblastoma RAS viral oncogene homolog, NRAS proto-oncogene, GTPase
External IDs	OMIM: 164790; MGI: 97376; HomoloGene: 55661; GeneCards: NRAS; OMA:NRAS - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	114,716,771 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	102,975,230 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; epithelium of nasopharynx; ; secondary oocyte; ; amniotic fluid; ; mucosa of colon; ; mucosa of sigmoid colon; ; germinal epithelium; ; skin of thigh; ; ganglionic eminence; ; parietal pleura;
	Top expressed in
	tail of embryo; ; genital tubercle; ; zygote; ; lactiferous gland; ; sciatic nerve; ; yolk sac; ; ventricular zone; ; corneal stroma; ; epithelium of lens; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein-containing complex binding; GTP binding; GTPase activity; protein binding;
Cellular component	Golgi apparatus; membrane; Golgi membrane; plasma membrane; extracellular exosome; tertiary granule membrane;
Biological process	epidermal growth factor receptor signaling pathway; stimulatory C-type lectin receptor signaling pathway; MAPK cascade; axon guidance; Fc-epsilon receptor signaling pathway; Ras protein signal transduction; leukocyte migration; signal transduction; ERBB2 signaling pathway; neutrophil degranulation; positive regulation of endothelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	4893
	18176
	ENSG00000213281
	ENSMUSG00000027852
	P01111
	P08556
	NM_002524
	NM_010937; NM_001368638
	NP_002515
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

NRAS is an enzyme that in humans is encoded by the NRAS gene. It was discovered by a small team of researchers led by Robin Weiss at the Institute of Cancer Research in London. It was the third RAS gene to be discovered, and was named NRAS, for its initial identification in human neuroblastoma cells.