Sodium voltage-gated channel alpha subunit 9

SCN9A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5EK0
Identifiers
Aliases	SCN9A, ETHA, FEB3B, GEFSP7, HSAN2D, NE-NA, NENA, Nav1.7, PN1, SFNP, sodium voltage-gated channel alpha subunit 9
External IDs	OMIM: 603415; MGI: 107636; HomoloGene: 2237; GeneCards: SCN9A; OMA:SCN9A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	166,376,001 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	66,465,306 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; spinal ganglia; ; stromal cell of endometrium; ; trigeminal ganglion; ; testicle; ; Achilles tendon; ; epithelium of colon; ; right lobe of liver; ; right testis; ; left testis;
	Top expressed in
	lumbar spinal ganglion; ; olfactory epithelium; ; trigeminal ganglion; ; superior cervical ganglion; ; median eminence; ; arcuate nucleus; ; supraoptic nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; ventromedial nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	sodium ion binding; sodium channel activity; voltage-gated ion channel activity; ion channel activity; voltage-gated sodium channel activity;
Cellular component	voltage-gated sodium channel complex; integral component of membrane; membrane; integral component of plasma membrane; cell projection; plasma membrane; axon;
Biological process	membrane depolarization during action potential; sodium ion transport; regulation of ion transmembrane transport; post-embryonic development; ion transport; behavioral response to pain; transmembrane transport; sensory perception of pain; inflammatory response; response to toxic substance; neuronal action potential; sodium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6335
	20274
	ENSG00000169432
	ENSMUSG00000075316
	Q15858
	Q62205
	NM_002977; NM_001365536
	NM_001290674; NM_001290675; NM_018852
	NP_002968; NP_001352465
	NP_001277603; NP_001277604
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium voltage-gated channel alpha subunit 9 (also Na_v1.7) is a sodium ion channel that, in humans, is encoded by the SCN9A gene. It is usually expressed at high levels in two types of neurons: the nociceptive (pain) neurons at the dorsal root ganglion (DRG) and trigeminal ganglion; and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system.