Naltriben

Naltriben
Clinical data
ATC code	none;
Identifiers
CAS Number	111555-58-9 ;
PubChem CID	5486827;
IUPHAR/BPS	1640;
ChemSpider	4589081 ;
UNII	RXG719F189;
ChEMBL	ChEMBL100940 ;
PDB ligand	ZY8 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID80912218 ;
Chemical and physical data
Formula	C26H25NO4
Molar mass	415.489 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc3c2O[C@H]6c1oc8ccccc8c1C[C@@]5(O)[C@H]4N(CC[C@@]56c2c(cc3)C4)CC7CC7;
	InChI InChI=1S/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1 ; Key:ZHVWWEYETMPAMX-IFKAHUTRSA-N ;
	(verify)

Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ₁ and δ₂ subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors. It also acts as a κ-opioid agonist at high doses.

Clinical data


ATC code	none
Identifiers
CAS Number	111555-58-9^Y
PubChem CID	5486827
IUPHAR/BPS	1640
ChemSpider	4589081^Y
UNII	RXG719F189
ChEMBL	ChEMBL100940^Y
PDB ligand	ZY8 (PDBe, RCSB PDB)
CompTox Dashboard (EPA)	DTXSID80912218
Chemical and physical data
Formula	C₂₆H₂₅NO₄
Molar mass	415.489 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Oc3c2O[C@H]6c1oc8ccccc8c1C[C@@]5(O)[C@H]4N(CC[C@@]56c2c(cc3)C4)CC7CC7
InChI InChI=1S/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1^Y Key:ZHVWWEYETMPAMX-IFKAHUTRSA-N^Y
(verify)