NT5C

NT5C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I7D, 4L57, 4YIH
Identifiers
Aliases	NT5C, DNT, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2, cdN, dNT-1, 5', 3'-nucleotidase, cytosolic
External IDs	OMIM: 191720; MGI: 1354954; HomoloGene: 8745; GeneCards: NT5C; OMA:NT5C - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,131,757 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,382,688 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right uterine tube; ; granulocyte; ; gastric mucosa; ; olfactory zone of nasal mucosa; ; left ovary; ; right lobe of thyroid gland; ; right ovary; ; ectocervix; ; body of stomach;
	Top expressed in
	left colon; ; epithelium of small intestine; ; thymus; ; duodenum; ; crypt of lieberkuhn of small intestine; ; ileum; ; adrenal gland; ; morula; ; endothelial cell of lymphatic vessel; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; 5'-nucleotidase activity; pyrimidine nucleotide binding; phosphatase activity; metal ion binding; nucleotidase activity; hydrolase activity;
Cellular component	cytoplasm; mitochondrion; extracellular exosome; nucleus; cytosol;
Biological process	pyrimidine deoxyribonucleotide catabolic process; purine nucleotide catabolic process; nucleotide metabolic process; pyrimidine nucleoside catabolic process; deoxyribonucleotide catabolic process; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	30833
	50773
	ENSG00000125458
	ENSMUSG00000020736
	Q8TCD5
	Q9JM14
	NM_001252377; NM_014595
	NM_015807
	NP_001239306; NP_055410
	NP_056622
	Wikidata
View/Edit Human	View/Edit Mouse

5', 3'-nucleotidase, cytosolic, also known as 5'(3')-deoxyribonucleotidase, cytosolic type (cdN) or deoxy-5'-nucleotidase 1 (dNT-1), is an enzyme that in humans is encoded by the NT5C gene on chromosome 17.

This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]