NPTN

NPTN
Identifiers
Aliases	NPTN, GP55, GP65, SDFR1, SDR1, np55, np65, neuroplastin
External IDs	OMIM: 612820; MGI: 108077; HomoloGene: 7531; GeneCards: NPTN; OMA:NPTN - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	73,634,134 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	58,657,955 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; lateral nuclear group of thalamus; ; cerebellar vermis; ; germinal epithelium; ; jejunal mucosa; ; tail of epididymis; ; bronchial epithelial cell; ; visceral pleura; ; orbitofrontal cortex; ; caput epididymis;
	Top expressed in
	nucleus accumbens; ; superior frontal gyrus; ; cerebellar cortex; ; olfactory tubercle; ; lobe of cerebellum; ; primary visual cortex; ; cerebellar vermis; ; cingulate gyrus; ; lateral geniculate nucleus; ; prefrontal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane transporter binding; fibroblast growth factor receptor binding; cell adhesion molecule binding; type 1 fibroblast growth factor receptor binding; cell-cell adhesion mediator activity; protein binding;
Cellular component	integral component of membrane; synaptic membrane; membrane; postsynaptic density; plasma membrane; inhibitory synapse; dendrite; presynaptic membrane; cell surface; axon; Schaffer collateral - CA1 synapse; glutamatergic synapse; GABA-ergic synapse; integral component of presynaptic active zone membrane; integral component of postsynaptic density membrane; immunological synapse;
Biological process	visual learning; positive regulation of long-term synaptic potentiation; nervous system development; cell adhesion; positive regulation of protein localization; positive regulation of ERK1 and ERK2 cascade; positive regulation of long-term neuronal synaptic plasticity; positive regulation of neuron projection development; positive regulation of cytosolic calcium ion concentration; homophilic cell adhesion via plasma membrane adhesion molecules; modulation of chemical synaptic transmission; synapse organization; regulation of receptor localization to synapse; excitatory synapse assembly; positive regulation of protein phosphorylation; positive regulation of fibroblast growth factor receptor signaling pathway; long-term potentiation; axon guidance; dendrite self-avoidance; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission; negative regulation of cytokine production; cellular calcium ion homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	27020
	20320
	ENSG00000156642
	ENSMUSG00000032336
	Q9Y639
	P97300
	NM_001161363; NM_001161364; NM_012428; NM_017455
	NM_001293673; NM_009145; NM_001357751
	NP_001154835; NP_001154836; NP_036560; NP_059429
	NP_001280602; NP_033171; NP_001344680; NP_001392991
	Wikidata
View/Edit Human	View/Edit Mouse

Neuroplastin is a protein that in humans is encoded by the NPTN gene.

Neuroplastin is a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. The alpha and beta transcripts show differential localization within the brain.

In 2014, in a study led by Dr. Sylvane Desrivières, of King's College London's Institute of Psychiatry found that "teenagers who had a highly functioning NPTN gene performed better in intelligence tests"