NOX1

NOX1
Identifiers
Aliases	NOX1, GP91-2, MOX1, NOH-1, NOH1, NADPH oxidase 1, NOH-1L
External IDs	OMIM: 300225; MGI: 2450016; HomoloGene: 48495; GeneCards: NOX1; OMA:NOX1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	100,874,359 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	133,122,705 bp
RNA expression pattern
	Top expressed in
	rectum; ; mucosa of sigmoid colon; ; mucosa of transverse colon; ; mucosa of ileum; ; epithelium of colon; ; testicle; ; buccal mucosa cell; ; pancreatic ductal cell; ; gonad; ; appendix;
	Top expressed in
	ileum; ; duodenum; ; colon; ; jejunum; ; secondary oocyte; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; primary oocyte; ; zygote; ; ventricular zone;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; voltage-gated ion channel activity; protein binding; NADP binding; oxidoreductase activity; superoxide-generating NAD(P)H oxidase activity;
Cellular component	cytoplasm; integral component of membrane; endosome; cell projection; membrane; plasma membrane; cell junction; NADPH oxidase complex; early endosome;
Biological process	cellular stress response to acidic pH; NADP metabolic process; intracellular pH elevation; cellular response to hyperoxia; regulation of ion transmembrane transport; extracellular matrix organization; positive regulation of JNK cascade; oxygen metabolic process; ion transport; positive regulation of integrin biosynthetic process; regulation of blood pressure; respiratory burst; hydrogen peroxide metabolic process; angiogenesis; positive regulation of cell population proliferation; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of vascular endothelial growth factor production; inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; cell migration; signal transduction; positive regulation of smooth muscle cell proliferation; positive regulation of MAPK cascade; ion transmembrane transport; superoxide anion generation; defense response;
	Sources:Amigo / QuickGO
Orthologs
	27035
	237038
	ENSG00000007952
	ENSMUSG00000031257
	Q9Y5S8
	Q8CIZ9
	NM_013955; NM_001271815; NM_007052; NM_013954
	NM_172203
	NP_001258744; NP_008983; NP_039249
	NP_757340
	Wikidata
View/Edit Human	View/Edit Mouse

NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene.

NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene.