Nucleolar protein 12 is a protein that in humans is encoded by the NOL12 gene. Human NOL12 has been shown to localize in the nucleolus and regulate nucleolar structure and homeostasis by maintaining the levels of multi-functional fibrillarin and nucleolin proteins. Its deficiency leads to p53 activation resulting in G2 arrest of cell. Nol12 or hNol12 drives p53 induced cell senescence suggesting its important role in aging. Human Nol12 is also required for ribosome maturation and genome integrity.
