NFIB (gene)

NFIB
Identifiers
Aliases	NFIB, CTF, HMGIC/NF-I/B, NF1-B, NFI-B, NFI-RED, NFIB2, NFIB3, nuclear factor I B, MACID
External IDs	OMIM: 600728; MGI: 103188; HomoloGene: 4087; GeneCards: NFIB; OMA:NFIB - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	14,398,983 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	82,623,987 bp
RNA expression pattern
	Top expressed in
	pericardium; ; epithelium of lactiferous gland; ; lactiferous duct; ; urethra; ; nipple; ; parietal pleura; ; mucosa of paranasal sinus; ; saphenous vein; ; vena cava; ; synovial joint;
	Top expressed in
	Rostral migratory stream; ; human fetus; ; ureter; ; pineal gland; ; semi-lunar valve; ; internal carotid artery; ; lactiferous gland; ; condyle; ; parotid gland; ; efferent ductule;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; double-stranded DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	intracellular anatomical structure; cerebellar mossy fiber; nucleus; fibrillar center;
Biological process	cell differentiation involved in salivary gland development; club cell differentiation; negative regulation of epithelial cell proliferation involved in lung morphogenesis; regulation of transcription, DNA-templated; negative regulation of mesenchymal cell proliferation involved in lung development; chondrocyte differentiation; lung development; negative regulation of DNA binding; salivary gland cavitation; hindbrain development; glial cell differentiation; negative regulation of transcription by RNA polymerase II; commissural neuron axon guidance; transcription, DNA-templated; anterior commissure morphogenesis; lung ciliated cell differentiation; DNA replication; type I pneumocyte differentiation; principal sensory nucleus of trigeminal nerve development; forebrain development; type II pneumocyte differentiation; positive regulation of transcription by RNA polymerase II; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of cell population proliferation; transcription by RNA polymerase II; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	4781
	18028
	ENSG00000147862
	ENSMUSG00000008575
	O00712
	P97863
	NM_001190737; NM_001190738; NM_001282787; NM_005596
	NM_001113209; NM_001113210; NM_001286127; NM_001286131; NM_008687
NP_001177666; NP_001177667; NP_001269716; NP_005587; NP_001356387;
	NP_001356388; NP_001356389; NP_001356390; NP_001356391; NP_001356392; NP_001356393; NP_001356394; NP_001356395; NP_001356396; NP_001356397; NP_001356398; NP_001356399; NP_001356400; NP_001356401; NP_001356402; NP_001356403; NP_001356404; NP_001356405; NP_001356406; NP_001356407; NP_001356408; NP_001356409; NP_001356410
	NP_001106680; NP_001106681; NP_001273056; NP_001273060; NP_032713
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear factor 1 B-type is a protein that in humans is encoded by the NFIB gene.

NFIB haploinsufficiency is also associated with intellectual disability and macrocephaly, as are NFIA and NFIX.