Neurogenin-3

NEUROG3
Identifiers
Aliases	NEUROG3, Atoh5, Math4B, NGN-3, bHLHa7, ngn3, neurogenin 3
External IDs	OMIM: 604882; MGI: 893591; HomoloGene: 40692; GeneCards: NEUROG3; OMA:NEUROG3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	69,573,422 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	61,970,542 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; duodenum; ; hippocampus proper; ; right adrenal cortex; ; rectum; ; smooth muscle tissue; ; right coronary artery; ; left adrenal gland; ; left adrenal cortex; ; serous sac;
	Top expressed in
	layer of hippocampus; ; primordial pancreas; ; molecular layer of dentate gyrus; ; radiate layer of hippocampus; ; lumbar spinal ganglion; ; Paneth cell; ; migratory enteric neural crest cell; ; granular layer of dentate gyrus; ; Region II of hippocampus proper; ; oriens layer of hippocampus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; double-stranded DNA binding; chromatin DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; intracellular anatomical structure; nucleus;
Biological process	neurogenesis; cell differentiation; peripheral nervous system development; regulation of transcription, DNA-templated; epithelial cell differentiation; hindbrain development; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; nervous system development; regulation of dendrite morphogenesis; multicellular organism development; central nervous system development; positive regulation of neuron differentiation; positive regulation of cell differentiation; spinal cord development; forebrain development; positive regulation of transcription by RNA polymerase II; transdifferentiation; endocrine pancreas development;
	Sources:Amigo / QuickGO
Orthologs
	50674
	11925
	ENSG00000122859
	ENSMUSG00000044312
	Q9Y4Z2
	P70661
	NM_020999
	NM_009719
	NP_066279
	NP_033849
	Wikidata
View/Edit Human	View/Edit Mouse

Neurogenin-3 (NGN3) is a protein that in humans is encoded by the Neurog3 gene.

Neurogenin-3 is a pro-endocrine transcription factor that is a member of the basic helix-loop-helix (bHLH) transcription factor and has a primary function of activating gene transcription in endocrine progenitor cells. It is a master regulator of pancreatic islet differentiation and regeneration and functions to directly enhance the expression of the lineage-committed transcription factors required for the differentiation of the endocrine progenitor cells into each of the endocrine cell subtypes.