NEIL3

NEIL3
Identifiers
Aliases	NEIL3, FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3, nei like DNA glycosylase 3
External IDs	OMIM: 608934; MGI: 2384588; HomoloGene: 10094; GeneCards: NEIL3; OMA:NEIL3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	177,362,936 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	54,092,100 bp
RNA expression pattern
	Top expressed in
	gonad; ; ventricular zone; ; testicle; ; secondary oocyte; ; ganglionic eminence; ; stromal cell of endometrium; ; bone marrow; ; pancreatic ductal cell; ; bone marrow cells; ; rectum;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; thymus; ; genital tubercle; ; spermatid; ; tail of embryo; ; tibiofemoral joint; ; fetal liver hematopoietic progenitor cell; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; zinc ion binding; hydrolase activity, hydrolyzing N-glycosyl compounds; metal ion binding; hydrolase activity, acting on glycosyl bonds; damaged DNA binding; catalytic activity; lyase activity; nucleic acid binding; hydrolase activity; DNA N-glycosylase activity; bubble DNA binding; DNA-(apurinic or apyrimidinic site) endonuclease activity; single-stranded DNA binding; double-stranded DNA binding; class I DNA-(apurinic or apyrimidinic site) endonuclease activity;
Cellular component	nucleoplasm; nucleus;
Biological process	nucleotide-excision repair; cellular response to DNA damage stimulus; metabolism; DNA repair; base-excision repair;
	Sources:Amigo / QuickGO
Orthologs
	55247
	234258
	ENSG00000109674
	ENSMUSG00000039396
	Q8TAT5
	Q8K203
	NM_018248
	NM_146208
	NP_060718
	NP_666320
	Wikidata
View/Edit Human	View/Edit Mouse

Nei endonuclease VIII-like 3 (E. coli) is a protein in humans that is encoded by the NEIL3 gene.

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.