NECAB3

NECAB3
Identifiers
Aliases	NECAB3, APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, N-terminal EF-hand calcium binding protein 3
External IDs	OMIM: 612478; MGI: 1861721; HomoloGene: 10992; GeneCards: NECAB3; OMA:NECAB3 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	33,674,463 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	154,400,810 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; left ovary; ; right ovary; ; muscle of thigh; ; apex of heart; ; gastric mucosa; ; gastrocnemius muscle; ; body of stomach; ; right lobe of thyroid gland;
	Top expressed in
	habenula; ; superior frontal gyrus; ; primary visual cortex; ; spermatid; ; dentate gyrus of hippocampal formation granule cell; ; lumbar spinal ganglion; ; embryo; ; prefrontal cortex; ; anterior horn of spinal cord; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; metal ion binding;
Cellular component	nucleus; cytoplasm; endoplasmic reticulum membrane; endoplasmic reticulum; Golgi cis cisterna; Golgi apparatus;
Biological process	protein secretion; protein metabolic process; regulation of amyloid precursor protein biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	63941
	56846
	ENSG00000125967
	ENSMUSG00000027489
	Q96P71
	Q9D6J4
	NM_031231; NM_031232
	NM_021546; NM_001379147; NM_001379148; NM_001379149
	NP_112508; NP_112509
	NP_067521; NP_001366076; NP_001366077; NP_001366078
	Wikidata
View/Edit Human	View/Edit Mouse

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.

The protein encoded by this gene interacts with the amino-terminal domain of the amyloid beta A4 precursor protein-binding family A member 2 (APBA2), inhibits the association of APBA2 with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by APBA2. This protein, together with APBA2, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.