NDUFS4

NDUFS4
Identifiers
Aliases	NDUFS4, AQDQ, CI-18, CI-18 kDa, CI-AQDQ, NADH:ubiquinone oxidoreductase subunit S4, MC1DN1
External IDs	OMIM: 602694; MGI: 1343135; HomoloGene: 1866; GeneCards: NDUFS4; OMA:NDUFS4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	53,683,338 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	114,524,794 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; gastrocnemius muscle; ; thoracic diaphragm; ; body of tongue; ; biceps brachii; ; left ventricle; ; apex of heart; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	intercostal muscle; ; digastric muscle; ; temporal muscle; ; right ventricle; ; muscle of thigh; ; sternocleidomastoid muscle; ; right kidney; ; triceps brachii muscle; ; ventricular zone; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on NAD(P)H; NADH dehydrogenase (ubiquinone) activity;
Cellular component	membrane; respiratory chain complex I; mitochondrion; mitochondrial inner membrane; respirasome; mitochondrial respiratory chain complex I;
Biological process	regulation of protein phosphorylation; positive regulation of fibroblast proliferation; reactive oxygen species metabolic process; mitochondrial respiratory chain complex I assembly; brain development; cellular respiration; response to cAMP; cAMP-mediated signaling; electron transport chain; mitochondrial electron transport, NADH to ubiquinone;
	Sources:Amigo / QuickGO
Orthologs
	4724
	17993
	ENSG00000164258
	ENSMUSG00000021764
	O43181
	Q9CXZ1
	NM_002495; NM_001318051
	NM_010887
	NP_001304980; NP_002486
	NP_035017
	Wikidata
View/Edit Human	View/Edit Mouse

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (NDUFS4) also known as NADH-ubiquinone oxidoreductase 18 kDa subunit is an enzyme that in humans is encoded by the NDUFS4 gene. This gene encodes a nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome.