NDUFA4

NDUFA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LEG, 1LEK, 1MWA, 2CKB
Identifiers
Aliases	NDUFA4, CI-9k, CI-MLRQ, MLRQ, mitochondrial complex associated, COXFA4, NDUFA4 mitochondrial complex associated, MC4DN21, MRCAF1, MISTR1
External IDs	OMIM: 603833; MGI: 107686; HomoloGene: 37629; GeneCards: NDUFA4; OMA:NDUFA4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	10,940,153 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; myocardium; ; cerebellar vermis; ; myocardium of left ventricle; ; Pons; ; cardiac muscle tissue of right atrium; ; prefrontal cortex; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; lateral nuclear group of thalamus;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity; cytochrome-c oxidase activity; protein binding; protein-containing complex binding;
Cellular component	mitochondrial inner membrane; mitochondrial respiratory chain complex I; respirasome; membrane; mitochondrion; mitochondrial respiratory chain complex IV;
Biological process	mitochondrial electron transport, NADH to ubiquinone; proton transmembrane transport; mitochondrial electron transport, cytochrome c to oxygen;
	Sources:Amigo / QuickGO
Orthologs
	4697
	17992
	ENSG00000189043
	ENSMUSG00000029632
	O00483
	Q62425
	NM_002489
	NM_010886
	NP_002480
	NP_035016
	Wikidata
View/Edit Human	View/Edit Mouse

NDUFA4, mitochondrial complex associated is a protein that in humans is encoded by the NDUFA4 gene. The NDUFA4 protein was first described to be a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. However, recent research has described NDUFA4 as a subunit of cytochrome c oxidase. Mutations in the NDUFA4 gene are associated with Leigh's syndrome.