NADH dehydrogenase (ubiquinone), alpha 1

NDUFA1
Identifiers
Aliases	NDUFA1, CI-MWFE, MWFE, ZNF183, NADH dehydrogenase (ubiquinone), alpha 1, NADH:ubiquinone oxidoreductase subunit A1, MC1DN12
External IDs	OMIM: 300078; MGI: 1929511; HomoloGene: 3337; GeneCards: NDUFA1; OMA:NDUFA1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	119,876,662 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	36,454,816 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; right ventricle; ; apex of heart; ; right auricle of heart; ; cardiac muscle tissue of right atrium; ; mucosa of transverse colon; ; Brodmann area 10; ; renal medulla; ; Brodmann area 9; ; muscle of thigh;
	Top expressed in
	Epithelium of choroid plexus; ; seminal vesicula; ; facial motor nucleus; ; vestibular membrane of cochlear duct; ; vestibular sensory epithelium; ; epithelium of lens; ; molar; ; right kidney; ; lobe of prostate; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity;
Cellular component	integral component of membrane; mitochondrion; mitochondrial respiratory chain complex I; respirasome; mitochondrial inner membrane; membrane; mitochondrial membranes; cytosol;
Biological process	mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly;
	Sources:Amigo / QuickGO
Orthologs
	4694
	54405
	ENSG00000125356
	ENSMUSG00000016427
	O15239
	O35683
	NM_004541
	NM_019443
	NP_004532
	NP_062316
	Wikidata
View/Edit Human	View/Edit Mouse

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 is a protein that in humans is encoded by the NDUFA1 gene. The NDUFA1 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Mutations in the NDUFA1 gene are associated with mitochondrial Complex I deficiency.