NBR1

NBR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WJ6, 2BKF, 2CP8, 2G4S, 2L8J, 2MGW, 2MJ5, 4OLE
Identifiers
Aliases	NBR1, 1A1-3B, IAI3B, M17S2, MIG19, neighbor of BRCA1 gene 1, autophagy cargo receptor, NBR1 autophagy cargo receptor
External IDs	OMIM: 166945; MGI: 108498; HomoloGene: 7438; GeneCards: NBR1; OMA:NBR1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	43,211,689 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,472,777 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; amniotic fluid; ; parietal pleura; ; epithelium of nasopharynx; ; germinal epithelium; ; Epithelium of choroid plexus; ; internal globus pallidus; ; jejunal mucosa; ; palpebral conjunctiva; ; visceral pleura;
	Top expressed in
	ciliary body; ; retinal pigment epithelium; ; spermatid; ; seminiferous tubule; ; lacrimal gland; ; utricle; ; iris; ; pituitary gland; ; motor neuron; ; sciatic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; zinc ion binding; protein binding; mitogen-activated protein kinase binding; ubiquitin binding;
Cellular component	cytoplasm; M band; autophagosome; cytosol; late endosome; lysosome; extracellular exosome; membrane; cytoplasmic vesicle; phagophore assembly site; mitochondrion; nucleoplasm; nuclear body; intracellular membrane-bounded organelle;
Biological process	protein complex oligomerization; negative regulation of osteoblast differentiation; regulation of stress-activated MAPK cascade; regulation of bone mineralization; macroautophagy;
	Sources:Amigo / QuickGO
Orthologs
	4077
	17966
	ENSG00000188554
	ENSMUSG00000017119
	Q14596
	P97432
	NM_001291571; NM_001291572; NM_005899; NM_031858; NM_031862
	NM_001252220; NM_001252222; NM_001252223; NM_008676
	NP_001278500; NP_001278501; NP_005890; NP_114068
	NP_001239149; NP_001239151; NP_001239152; NP_032702
	Wikidata
View/Edit Human	View/Edit Mouse

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene. One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.