NAV2

NAV2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2YRN
Identifiers
Aliases	NAV2, HELAD1, POMFIL2, RAINB1, STEERIN2, UNC53H2, neuron navigator 2
External IDs	OMIM: 607026; MGI: 2183691; HomoloGene: 52330; GeneCards: NAV2; OMA:NAV2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	20,121,601 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	49,610,090 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; tail of epididymis; ; corpus epididymis; ; visceral pleura; ; internal globus pallidus; ; bronchial epithelial cell; ; caput epididymis; ; oocyte; ; epithelium of lactiferous gland; ; Medulla Oblongata;
	Top expressed in
	zygote; ; ascending aorta; ; granular layer; ; aortic valve; ; cardiac muscle tissue of left ventricle; ; secondary oocyte; ; choroid plexus of fourth ventricle; ; extraocular muscle; ; plantaris muscle; ; extensor digitorum longus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; heparin binding; protein binding; ATP binding; hydrolase activity; helicase activity;
Cellular component	interstitial matrix; nucleus; nucleoplasm; extracellular matrix;
Biological process	vagus nerve development; sensory perception of smell; glossopharyngeal nerve development; regulation of systemic arterial blood pressure by baroreceptor feedback; hearing; locomotory behavior; optic nerve development; nervous system development; neurogenesis;
	Sources:Amigo / QuickGO
Orthologs
	89797
	78286
	ENSG00000166833
	ENSMUSG00000052512
	Q8IVL1
	n/a
	NM_001111018; NM_001111019; NM_001244963; NM_145117; NM_182964
	NM_001111016; NM_175272
	NP_001104488; NP_001104489; NP_001231892; NP_660093; NP_892009
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Neuron navigator 2 is a protein that in humans is encoded by the NAV2 gene. The vitamin A metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal development, including neurite outgrowth. NAV2 is an atRA-responsive gene.

The neuron navigator, Is also theorized to play a role in cellular growth and migration. In addition, different isoform variants have been discovered for this gene. Connections have been drawn to Nav2 having an association with human neurocognitive disorders Alzheimer's disease and age-related phenotypes. It has been discussed that future studies of Nav2 could provide crucial information in understanding the pathophysiology of the disease and its related phenotypes.