N1-Acetyl-5-methoxykynuramine

N1-Acetyl-5-methoxykynuramine
Names
	IUPAC name N-[3-(2-Amino-5-methoxyphenyl)-3-oxopropyl]acetamide
Identifiers
CAS Number	52450-39-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:173696;
ChEMBL	ChEMBL369941;
ChemSpider	346276;
PubChem CID	UNII 3906582.3.2 UNII;
CompTox Dashboard (EPA)	DTXSID10966880 ;
	InChI InChI=1S/C12H16N2O3/c1-8(15)14-6-5-12(16)10-7-9(17-2)3-4-11(10)13/h3-4,7H,5-6,13H2,1-2H3,(H,14,15) Key: RJQIZOKNUKRKTP-UHFFFAOYSA-N;
	SMILES CC(=O)NCCC(=O)C1=C(C=CC(=C1)OC)N;
Properties
Chemical formula	C12H16N2O3
Molar mass	236.271 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

N1-Acetyl-5-methoxykynuramine (AMK) is a metabolite of melatonin that could improve memory by acting on the melatonin receptors. AMK is produced from the metabolization of melatonin by the kynuramine pathway in the brain. It significantly increased the phosphorylation of both ERK and CREB in the hippocampus. It also helps scavenge free radicals. AMK is highly reactive towards dioxygen (O₂) radicals because of AMK's N^2-amino group.