Mucin 5AC

MUC5AC
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	5AJN, 5AJP, 5AJO
Identifiers
Aliases	MUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming
External IDs	OMIM: 158373; MGI: 104697; HomoloGene: 137237; GeneCards: MUC5AC; OMA:MUC5AC - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,201,138 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,372,968 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; gastric mucosa; ; body of stomach; ; fundus; ; gallbladder; ; canal of the cervix; ; islet of Langerhans; ; appendix; ; urinary bladder; ; muscle tissue;
	Top expressed in
	pyloric antrum; ; epithelium of stomach; ; mucous cell of stomach; ; conjunctival fornix; ; duodenum; ; olfactory epithelium; ; quadriceps femoris muscle; ; esophagus; ; cornea; ; pancreas;
	More reference expression data
	n/a
Gene ontology
Molecular function	extracellular matrix structural constituent;
Cellular component	cytoplasm; Golgi lumen; extracellular region; extracellular exosome; extracellular space; plasma membrane; mucus layer;
Biological process	phosphatidylinositol-mediated signaling; O-glycan processing; stimulatory C-type lectin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4586
	17833
	ENSG00000215182; ENSG00000283158
	ENSMUSG00000037974
	P98088
	n/a
	NM_017511; NM_001304359
	NM_010844
	NP_001291288
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans.

MUC-5AC is a large gel-forming glycoprotein. In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance. Overproduction of MUC-5AC can contribute to diseases such as asthma and chronic obstructive pulmonary disease, and has also been associated with greater protection against influenza infection.