Myopalladin

MYPN
Identifiers
Aliases	MYPN, CMD1DD, CMH22, MYOP, RCM4, myopalladin, NEM11
External IDs	OMIM: 608517; MGI: 1916052; HomoloGene: 23778; GeneCards: MYPN; OMA:MYPN - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	68,212,017 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	63,039,731 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; deltoid muscle; ; tibialis anterior muscle; ; Skeletal muscle tissue of biceps brachii; ; myocardium of left ventricle; ; apex of heart; ; right auricle of heart;
	Top expressed in
	medial head of gastrocnemius muscle; ; knee joint; ; triceps brachii muscle; ; extraocular muscle; ; vastus lateralis muscle; ; ankle; ; temporal muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; tibialis anterior muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding; cytoskeletal protein binding; actin binding; protein binding; muscle alpha-actinin binding; actin filament binding; cell-cell adhesion mediator activity;
Cellular component	cytoplasm; sarcomere; Z discdkac; I band; nucleus; plasma membrane; axon;
Biological process	sarcomere organization; regulation of cell migration; regulation of cytoskeleton organization; homophilic cell adhesion via plasma membrane adhesion molecules; axon guidance; dendrite self-avoidance;
	Sources:Amigo / QuickGO
Orthologs
	84665
	68802
	ENSG00000138347
	ENSMUSG00000020067
	Q86TC9
	Q5DTJ9
	NM_001256267; NM_001256268; NM_032578
	NM_182992
	NP_001243196; NP_001243197; NP_115967
	NP_892037
	Wikidata
View/Edit Human	View/Edit Mouse

Myopalladin is a protein that in humans is encoded by the MYPN gene. Myopalladin is a muscle protein responsible for tethering proteins at the Z-disc and for communicating between the sarcomere and the nucleus in cardiac and skeletal muscle