Myosin-7

MYH7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DTP, 4DB1, 4P7H, 4XA1, 4XA3, 4XA4, 4XA6, 4PA0, 5CHX, 5CJ0, 5CJ4, 5CJ1, 2FXO, 2FXM
Identifiers
Aliases	MYH7, CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM, myosin, heavy chain 7, cardiac muscle, beta, myosin heavy chain 7
External IDs	OMIM: 160760; MGI: 2155600; HomoloGene: 68044; GeneCards: MYH7; OMA:MYH7 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,435,660 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,232,083 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; Skeletal muscle tissue of biceps brachii; ; gastrocnemius muscle; ; right ventricle; ; left ventricle; ; glutes; ; triceps brachii muscle; ; myocardium of left ventricle; ; vastus lateralis muscle;
	Top expressed in
	soleus muscle; ; atrioventricular valve; ; endocardial cushion; ; ankle; ; plantaris muscle; ; cardiac muscle tissue of left ventricle; ; extraocular muscle; ; thoracic diaphragm; ; intercostal muscle; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; calmodulin binding; protein binding; actin binding; cytoskeletal motor activity; ATP binding; ATPase activity; microfilament motor activity; actin filament binding; microtubule motor activity; microtubule binding;
Cellular component	cytoplasm; stress fiber; Z discdkac; myosin filament; myosin complex; muscle myosin complex; myofibril; sarcomere;
Biological process	cardiac muscle contraction; adult heart development; transition between fast and slow fiber; regulation of the force of heart contraction; skeletal muscle contraction; regulation of slow-twitch skeletal muscle fiber contraction; regulation of heart rate; ventricular cardiac muscle tissue morphogenesis; ATP metabolic process; muscle filament sliding; striated muscle contraction; regulation of the force of skeletal muscle contraction; muscle contraction; cardiac muscle hypertrophy in response to stress; microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	4625
	140781
	ENSG00000092054
	ENSMUSG00000053093
	P12883
	Q91Z83
	NM_000257
	NM_080728; NM_001361607
	NP_000248
	NP_542766; NP_001348536
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-7 is a protein that in humans is encoded by the MYH7 gene.

It is the myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in skeletal muscles (type I fibers). This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α. MHC-β is the major protein comprising the thick filament that forms the sarcomeres in cardiac muscle and plays a major role in cardiac muscle contraction.