MTRR (gene)

MTRR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QTL, 2QTZ
Identifiers
Aliases	MTRR, MSR, cblE, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
External IDs	OMIM: 602568; MGI: 1891037; HomoloGene: 11419; GeneCards: MTRR; OMA:MTRR - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	7,906,025 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	68,730,268 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pancreatic ductal cell; ; Epithelium of choroid plexus; ; upper lobe of left lung; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; kidney tubule; ; right ventricle; ; monocyte; ; rectum;
	Top expressed in
	renal corpuscle; ; yolk sac; ; muscle of thigh; ; medullary collecting duct; ; tail of embryo; ; spermatocyte; ; genital tubercle; ; ureter; ; blastocyst; ; skeletal muscle tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	FMN binding; NADPH-hemoprotein reductase activity; flavin adenine dinucleotide binding; FAD binding; protein binding; NADP binding; NADPH binding; oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor; oxidoreductase activity; (Methionine synthase) reductase; [methionine synthase reductase activity];
Cellular component	cytosol; cytoplasm;
Biological process	cobalamin metabolic process; cellular amino acid biosynthetic process; methionine biosynthetic process; DNA methylation; methionine metabolic process; homocysteine catabolic process; folic acid metabolic process; negative regulation of cystathionine beta-synthase activity; S-adenosylmethionine cycle; homocysteine metabolic process; sulfur amino acid metabolic process; methylation;
	Sources:Amigo / QuickGO
Orthologs
	4552
	210009
	ENSG00000124275
	ENSMUSG00000034617
	Q9UBK8
	Q8C1A3
	NM_002454; NM_024010
	NM_172480; NM_001308475
	NP_002445; NP_076915; NP_001351369; NP_001351370; NP_001351371
	NP_001295404; NP_766068
	Wikidata
View/Edit Human	View/Edit Mouse

Methionine synthase reductase, also known as MSR, is an enzyme that in humans is encoded by the MTRR gene.