MTHFD2L

MTHFD2L
Identifiers
Aliases	MTHFD2L, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
External IDs	OMIM: 614047; MGI: 1915871; HomoloGene: 28295; GeneCards: MTHFD2L; OMA:MTHFD2L - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	74,303,099 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	91,021,368 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; right lobe of liver; ; Achilles tendon; ; testicle; ; monocyte; ; olfactory zone of nasal mucosa; ; ganglionic eminence; ; epithelium of colon; ; ventricular zone; ; left adrenal cortex;
	Top expressed in
	ventricular zone; ; medial ganglionic eminence; ; neural tube; ; hand; ; right kidney; ; genital tubercle; ; lobe of prostate; ; parotid gland; ; lacrimal gland; ; olfactory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; catalytic activity; hydrolase activity; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity;
Cellular component	mitochondrial inner membrane; membrane; mitochondrion; cytosol; mitochondrial matrix;
Biological process	purine nucleotide biosynthetic process; methionine biosynthetic process; tetrahydrofolate interconversion; metabolism; histidine biosynthetic process; cellular amino acid biosynthetic process; one-carbon metabolic process; 10-formyltetrahydrofolate metabolic process; folic acid metabolic process; tetrahydrofolate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	441024
	665563
	ENSG00000163738
	ENSMUSG00000029376
	Q9H903; Q8IY64
	D3YZG8
NM_001004346; NM_001144978; NM_001351310; NM_001351311; NM_001351314;
	NM_001351329; NM_001351331
	NM_026788
NP_001004346; NP_001138450; NP_001338239; NP_001338240; NP_001338243;
	NP_001338258; NP_001338260
	NP_081064
	Wikidata
View/Edit Human	View/Edit Mouse

NAD-dependent methylenetetrahydrofolate dehydrogenase 2-like protein (MTHFD2L), also known as bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, is an enzyme that in humans is encoded by the MTHFD2L gene on chromosome 4. This enzyme localizes to the inner mitochondrial membrane, where it performs the NADP+-dependent dehydrogenase/cyclohydrolase activity as part of the mitochondrial pathway to convert folate to formate. It is associated with fluctuations in cytokine secretion in response to viral infections and vaccines.