MSC (gene)

MSC
Identifiers
Aliases	MSC, ABF-1, ABF1, MYOR, bHLHa22, musculin
External IDs	OMIM: 603628; MGI: 1333884; HomoloGene: 3738; GeneCards: MSC; OMA:MSC - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	71,844,412 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	14,826,216 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; left coronary artery; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; testicle; ; stromal cell of endometrium; ; gallbladder; ; apex of heart; ; tibial arteries;
	Top expressed in
	mesenteric lymph nodes; ; morula; ; blastocyst; ; internal carotid artery; ; embryo; ; embryo; ; thymus; ; optic nerve; ; Gonadal ridge; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein dimerization activity; transcription corepressor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	roof of mouth development; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; branchiomeric skeletal muscle development; transcription, DNA-templated; diaphragm development; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	9242
	17681
	ENSG00000178860
	ENSMUSG00000025930
	O60682
	O88940
	NM_005098
	NM_010827; NM_001360810
	NP_005089
	NP_034957; NP_001347739
	Wikidata
View/Edit Human	View/Edit Mouse

Musculin is a protein that in humans is encoded by the MSC gene.

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.