MRPS28

MRPS28
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J9M
Identifiers
Aliases	MRPS28, MRP-S28, MRP-S35, MRPS35, HSPC007, mitochondrial ribosomal protein S28, COXPD47
External IDs	OMIM: 611990; MGI: 1913480; HomoloGene: 8519; GeneCards: MRPS28; OMA:MRPS28 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	80,030,289 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	8,988,978 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; muscle of thigh; ; left adrenal cortex; ; gastrocnemius muscle; ; islet of Langerhans; ; left ventricle; ; substantia nigra; ; skeletal muscle tissue;
	Top expressed in
	triceps brachii muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; digastric muscle; ; soleus muscle; ; skeletal muscle tissue; ; extraocular muscle; ; quadriceps femoris muscle; ; tibialis anterior muscle; ; thoracic diaphragm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrion; mitochondrial small ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; biological process;
	Sources:Amigo / QuickGO
Orthologs
	28957
	66230
	ENSG00000147586
	ENSMUSG00000040269
	Q9Y2Q9
	Q9CY16
	NM_014018
	NM_025434
	NP_054737
	NP_079710
	Wikidata
View/Edit Human	View/Edit Mouse

28S ribosomal protein S28, mitochondrial is a protein that in humans is encoded by the MRPS28 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature.