Mitochondrial ribosomal protein L19

MRPL19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Identifiers
Aliases	MRPL19, L19mt, MRP-L15, MRP-L19, MRPL15, RLX1, RPML15, mitochondrial ribosomal protein L19
External IDs	OMIM: 611832; MGI: 1926274; HomoloGene: 8851; GeneCards: MRPL19; OMA:MRPL19 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	75,690,851 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	81,942,939 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; right adrenal gland; ; Skeletal muscle tissue of biceps brachii; ; left adrenal gland; ; rectum; ; right adrenal cortex; ; gingival epithelium; ; left adrenal cortex; ; islet of Langerhans; ; muscle of thigh;
	Top expressed in
	endocardial cushion; ; medullary collecting duct; ; epiblast; ; otic placode; ; migratory enteric neural crest cell; ; blastocyst; ; atrioventricular valve; ; atrium; ; renal corpuscle; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome;
Cellular component	mitochondrial inner membrane; ribosome; nuclear membrane; intracellular anatomical structure; nucleus; mitochondrion; mitochondrial large ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	9801
	56284
	ENSG00000115364
	ENSMUSG00000030045
	P49406
	Q9D338
	NM_014763
	NM_026490
	NP_055578
	NP_080766
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L19, mitochondrial is a protein that in humans is encoded by the MRPL19 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.