MMP24

MMP24
Identifiers
Aliases	MMP24, MMP-24, MMP25, MT-MMP 5, MT-MMP5, MT5-MMP, MT5MMP, MTMMP5, matrix metallopeptidase 24
External IDs	OMIM: 604871; MGI: 1341867; HomoloGene: 21331; GeneCards: MMP24; OMA:MMP24 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,276,998 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,660,286 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; tendon of biceps brachii; ; buccal mucosa cell; ; cerebellar vermis; ; internal globus pallidus; ; prefrontal cortex; ; right frontal lobe; ; pars reticulata; ; paraflocculus of cerebellum; ; ganglionic eminence;
	Top expressed in
	cerebellar cortex; ; lobe of cerebellum; ; cerebellar vermis; ; gastrula; ; supraoptic nucleus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; ganglionic eminence; ; ascending aorta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; cadherin binding; metal ion binding; peptidase activity; enzyme activator activity; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity;
Cellular component	integral component of membrane; Golgi apparatus; trans-Golgi network membrane; membrane; extracellular matrix; plasma membrane; integral component of plasma membrane; extracellular region; extracellular exosome; extracellular space;
Biological process	glial cell differentiation; proteolysis; detection of temperature stimulus involved in sensory perception of pain; neuronal stem cell population maintenance; cell-cell adhesion mediated by cadherin; cell adhesion; positive regulation of catalytic activity; cell-cell adhesion via plasma-membrane adhesion molecules; extracellular matrix organization; collagen catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10893
	17391
	ENSG00000125966
	ENSMUSG00000027612
	Q9Y5R2
	Q9R0S2
	NM_006690
	NM_010808
	NP_006681
	NP_034938
	Wikidata
View/Edit Human	View/Edit Mouse

Matrix metalloproteinase-24 is an enzyme that in humans is encoded by the MMP24 gene.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24.