MGAT3

MGAT3
Identifiers
Aliases	MGAT3, GNT-III, GNT3, mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
External IDs	OMIM: 604621; MGI: 104532; HomoloGene: 31088; GeneCards: MGAT3; OMA:MGAT3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,492,194 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	80,099,720 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; prefrontal cortex; ; Brodmann area 9; ; olfactory bulb; ; nucleus accumbens; ; cingulate gyrus; ; dorsal motor nucleus of vagus nerve; ; Amygdala; ; anterior cingulate cortex;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; right kidney; ; primary visual cortex; ; cerebellar cortex; ; proximal tubule; ; supraoptic nucleus; ; lumbar subsegment of spinal cord; ; facial motor nucleus; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	protein glycosylation; protein N-linked glycosylation; N-acetylglucosamine metabolic process; protein localization; regulation of cell migration; cellular response to oxidative stress; amyloid-beta metabolic process; cognition; positive regulation of protein localization to early endosome; negative regulation of lysosomal protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4248
	17309
	ENSG00000128268
	ENSMUSG00000042428
	Q09327
	Q10470; Q5RKT9
	NM_001098270; NM_002409
	NM_010795
	NP_001091740; NP_002400
	NP_034925
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT3 gene.

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.