Malate dehydrogenase 2

MDH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DFD, 4WLE, 4WLO, 4WLV, 4WLN, 4WLU, 4WLF
Identifiers
Aliases	MDH2, M-MDH, MDH, MGC:3559, MOR1, Malate dehydrogenase 2, EIEE51, DEE51
External IDs	OMIM: 154100; MGI: 97050; HomoloGene: 55938; GeneCards: MDH2; OMA:MDH2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	76,067,508 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,819,252 bp
RNA expression pattern
	Top expressed in
	body of tongue; ; right ventricle; ; beta cell; ; Skeletal muscle tissue of rectus abdominis; ; gastrocnemius muscle; ; mucosa of pharynx; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; human penis;
	Top expressed in
	plantaris muscle; ; extensor digitorum longus muscle; ; digastric muscle; ; cardiac muscle tissue of left ventricle; ; sternocleidomastoid muscle; ; right ventricle; ; temporal muscle; ; extraocular muscle; ; interventricular septum; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; malate dehydrogenase activity; protein self-association; catalytic activity; L-malate dehydrogenase activity; oxidoreductase activity; malate dehydrogenase (NADP+) activity; RNA binding;
Cellular component	membrane; myelin sheath; mitochondrial matrix; mitochondrion; mitochondrial inner membrane; extracellular exosome; nucleus; cytoplasm;
Biological process	gluconeogenesis; malate metabolic process; carboxylic acid metabolic process; internal protein amino acid acetylation; tricarboxylic acid cycle; oxaloacetate metabolic process; NADH metabolic process; aerobic respiration; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4191
	17448
	ENSG00000146701
	ENSMUSG00000019179
	P40926
	P08249
	NM_001282403; NM_001282404; NM_005918
	NM_008617
	NP_001269332; NP_001269333; NP_005909
	NP_032643
	Wikidata
View/Edit Human	View/Edit Mouse

Malate dehydrogenase, mitochondrial also known as malate dehydrogenase 2 is an enzyme that in humans is encoded by the MDH2 gene.

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.