MDH1

MDH1
Identifiers
Aliases	MDH1, HEL-S-32, MDH-s, MDHA, MGC:1375, MOR2, malate dehydrogenase 1, EIEE88, DEE88, KAR
External IDs	OMIM: 154200; MGI: 97051; HomoloGene: 4324; GeneCards: MDH1; OMA:MDH1 - orthologs
EC number	1.1.1.96
Gene location (Human)
Chr.	Chromosome 2 (human)
End	63,607,197 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	21,522,367 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; right ventricle; ; Pons; ; middle temporal gyrus; ; Brodmann area 10; ; orbitofrontal cortex; ; left ventricle; ; apex of heart; ; right auricle of heart; ; Brodmann area 46;
	Top expressed in
	medial vestibular nucleus; ; ventral tegmental area; ; habenula; ; mammillary body; ; dorsal tegmental nucleus; ; Epithelium of choroid plexus; ; medial dorsal nucleus; ; lateral hypothalamus; ; facial motor nucleus; ; substantia nigra;
	More reference expression data
	n/a
Gene ontology
Molecular function	malic enzyme activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; oxidoreductase activity; protein binding; diiodophenylpyruvate reductase activity; malate dehydrogenase activity; NAD binding; catalytic activity; L-malate dehydrogenase activity;
Cellular component	extracellular exosome; myelin sheath; extracellular space; cytoplasm; mitochondrion; cytosol;
Biological process	gluconeogenesis; NAD metabolic process; carboxylic acid metabolic process; tricarboxylic acid cycle; oxaloacetate metabolic process; malate metabolic process; NADH metabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4190
	17449
	ENSG00000014641
	ENSMUSG00000020321
	P40925
	P14152
	NM_005917; NM_001199111; NM_001199112; NM_001316374
	NM_008618; NM_001316675
	NP_001186040; NP_001186041; NP_001303303; NP_005908
	NP_001303604; NP_032644
	Wikidata
View/Edit Human	View/Edit Mouse

Malate dehydrogenase, cytoplasmic also known as malate dehydrogenase 1 is an enzyme that in humans is encoded by the MDH1 gene.