Mitochondrial antiviral-signaling protein

MAVS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MS7, 2MS8, 3J6C, 3J6J, 3RC5, 4P4H, 4Z8M, 5JEK
Identifiers
Aliases	MAVS, CARDIF, IPS-1, IPS1, VISA, mitochondrial antiviral signaling protein
External IDs	OMIM: 609676; MGI: 2444773; HomoloGene: 17004; GeneCards: MAVS; OMA:MAVS - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	3,876,123 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	131,089,945 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; right ventricle; ; mucosa of colon; ; lactiferous duct; ; mucosa of sigmoid colon; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; gastrocnemius muscle; ; external globus pallidus; ; jejunum;
	Top expressed in
	epithelium of small intestine; ; parotid gland; ; soleus muscle; ; myocardium of ventricle; ; otic vesicle; ; intercostal muscle; ; liver; ; digastric muscle; ; brown adipose tissue; ; thoracic diaphragm;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; protein binding; CARD domain binding; protein kinase binding;
Cellular component	integral component of membrane; mitochondrial membranes; membrane; peroxisomal membrane; peroxisome; mitochondrial outer membrane; mitochondrion;
Biological process	positive regulation of type I interferon-mediated signaling pathway; positive regulation of protein phosphorylation; positive regulation of interferon-alpha production; immune system process; regulation of peroxisome organization; positive regulation of DNA-binding transcription factor activity; positive regulation of IP-10 production; negative regulation of viral genome replication; defense response to bacterium; positive regulation of chemokine (C-C motif) ligand 5 production; positive regulation of interleukin-8 production; cellular response to exogenous dsRNA; activation of innate immune response; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of type I interferon production; innate immune response; viral process; positive regulation of type I interferon production; signal transduction; RIG-I signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of defense response to virus by host; positive regulation of interferon-beta production; protein deubiquitination; positive regulation of response to cytokine stimulus; defense response to virus;
	Sources:Amigo / QuickGO
Orthologs
	57506
	228607
	ENSG00000088888
	ENSMUSG00000037523
	Q7Z434
	Q8VCF0
	NM_001206491; NM_020746; NM_001385663
	NM_001206382; NM_001206383; NM_001206385; NM_144888
	NP_001193420; NP_065797
	NP_001193311; NP_001193312; NP_001193314; NP_659137
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial antiviral-signaling protein (MAVS) is a protein that is essential for antiviral innate immunity. MAVS is located in the outer membrane of the mitochondria, peroxisomes, and mitochondrial-associated endoplasmic reticulum membrane (MAM). Upon viral infection, a group of cytosolic proteins will detect the presence of the virus and bind to MAVS, thereby activating MAVS. The activation of MAVS leads the virally infected cell to secrete cytokines. This induces an immune response which kills the host's virally infected cells, resulting in clearance of the virus.