Megakaryocyte-associated tyrosine kinase

MATK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JWO, 1X6G, 3US4
Identifiers
Aliases	MATK, CHK, CTK, HHYLTK, HYL, HYLTK, Lsk, Megakaryocyte-associated tyrosine kinase
External IDs	OMIM: 600038; MGI: 99259; HomoloGene: 48104; GeneCards: MATK; OMA:MATK - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,802,129 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,099,199 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; Brodmann area 9; ; Amygdala; ; prefrontal cortex; ; nucleus accumbens; ; putamen; ; caudate nucleus;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord; ; entorhinal cortex; ; perirhinal cortex; ; hippocampus proper; ; olfactory tubercle; ; subiculum; ; lateral septal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein binding; protein tyrosine kinase activity; signaling receptor binding; ATP binding;
Cellular component	cytoplasm; cytosol; membrane; extrinsic component of cytoplasmic side of plasma membrane;
Biological process	cell differentiation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; protein phosphorylation; positive regulation of cell population proliferation; peptidyl-tyrosine autophosphorylation; mesoderm development; cell population proliferation; innate immune response; ERBB2 signaling pathway; peptidyl-tyrosine phosphorylation; regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	4145
	17179
	ENSG00000007264
	ENSMUSG00000004933
	P42679
	P41242
	NM_002378; NM_139354; NM_139355
	NM_001285853; NM_001285854; NM_001285855; NM_010768
	NP_002369; NP_647611; NP_647612
	NP_001272782; NP_001272783; NP_001272784; NP_034898
	Wikidata
View/Edit Human	View/Edit Mouse

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.