MAPK8IP1

MAPK8IP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G01, 2GMX, 2H96, 3OXI, 3PTG, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4E73, 4G1W, 4H39, 4HYS, 4HYU, 4IZY
Identifiers
Aliases	MAPK8IP1, IB1, JIP-1, JIP1, PRKM8IP, mitogen-activated protein kinase 8 interacting protein 1
External IDs	OMIM: 604641; MGI: 1309464; HomoloGene: 31314; GeneCards: MAPK8IP1; OMA:MAPK8IP1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	45,906,465 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	92,231,608 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right frontal lobe; ; anterior pituitary; ; right hemisphere of cerebellum; ; tibial nerve; ; anterior cingulate cortex; ; prefrontal cortex; ; ventricular zone; ; Brodmann area 9; ; Brodmann area 10;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; entorhinal cortex; ; perirhinal cortex; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior surface of tongue; ; gallbladder; ; dorsomedial hypothalamic nucleus; ; central gray substance of midbrain;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	MAP-kinase scaffold activity; protein kinase inhibitor activity; protein binding; kinesin binding; protein kinase binding; JUN kinase binding; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding;
Cellular component	cytoplasm; cell body; cytosol; dendritic growth cone; endoplasmic reticulum membrane; mitochondrial membranes; membrane; dentate gyrus mossy fiber; axonal growth cone; synapse; axon; dendrite; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; neuron projection; nucleus; plasma membrane;
Biological process	regulation of transcription, DNA-templated; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of apoptotic process; negative regulation of JNK cascade; regulation of JNK cascade; JUN phosphorylation; negative regulation of JUN kinase activity; vesicle-mediated transport; signal transduction; positive regulation of MAPK cascade; positive regulation of JNK cascade; regulation of CD8-positive, alpha-beta T cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	9479
	19099
	ENSG00000121653
	ENSMUSG00000027223
	Q9UQF2
	Q9WVI9
	NM_005456
	NM_001202445; NM_001202446; NM_011162
	NP_005447
	NP_001189374; NP_001189375; NP_035292
	Wikidata
View/Edit Human	View/Edit Mouse

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.