MAP1LC3B

MAP1LC3B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V49, 2LUE, 2ZJD, 3VTU, 3VTV, 3VTW, 3WAO, 3X0W, 4WAA, 5D94, 5DCN
Identifiers
Aliases	MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a, microtubule associated protein 1 light chain 3 beta
External IDs	OMIM: 609604; MGI: 1914693; HomoloGene: 69359; GeneCards: MAP1LC3B; OMA:MAP1LC3B - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	87,404,779 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	122,325,499 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; pars compacta; ; Brodmann area 10; ; pars reticulata; ; lateral nuclear group of thalamus; ; frontal pole; ; C1 segment; ; postcentral gyrus; ; external globus pallidus; ; Pons;
	Top expressed in
	external carotid artery; ; morula; ; deep cerebellar nuclei; ; internal carotid artery; ; medial vestibular nucleus; ; blastocyst; ; pontine nuclei; ; iris; ; ciliary body; ; dorsal tegmental nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase binding; microtubule binding;
Cellular component	cytoplasm; organelle membrane; membrane; intracellular anatomical structure; mitochondrion; axoneme; microtubule; cytoskeleton; cytoplasmic vesicle; endomembrane system; autophagosome membrane; cytosol; autophagosome; autolysosome;
Biological process	autophagy of mitochondrion; autophagosome assembly; autophagy; cellular response to nitrogen starvation; cellular response to starvation; macroautophagy; autophagosome maturation; positive regulation of mucus secretion;
	Sources:Amigo / QuickGO
Orthologs
	81631
	67443
	ENSG00000140941
	ENSMUSG00000031812
	Q9GZQ8
	Q9CQV6
	NM_022818
	NM_026160; NM_001364358
	NP_073729
	NP_080436; NP_001351287
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene. LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes.