MAL2 (gene)

MAL2
Identifiers
Aliases	MAL2, mal, T-cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2
External IDs	OMIM: 609684; MGI: 2146021; HomoloGene: 14167; GeneCards: MAL2; OMA:MAL2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	119,245,673 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	54,466,243 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; oral cavity; ; mucosa of pharynx; ; nasal epithelium; ; amniotic fluid; ; palpebral conjunctiva; ; human penis; ; gums; ; mucosa of colon; ; mucosa of sigmoid colon;
	Top expressed in
	subiculum; ; right lung lobe; ; epithelium of stomach; ; Region I of hippocampus proper; ; primary motor cortex; ; mucous cell of stomach; ; cingulate gyrus; ; conjunctival fornix; ; anterior amygdaloid area; ; prefrontal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; structural constituent of myelin sheath;
Cellular component	cytoplasm; perinuclear region of cytoplasm; plasma membrane; extracellular exosome; apical plasma membrane; membrane; endomembrane system; membrane raft; integral component of membrane; integral component of synaptic vesicle membrane; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse;
Biological process	transcytosis; membrane raft polarization; protein localization; myelination;
	Sources:Amigo / QuickGO
Orthologs
	114569
	105853
	ENSG00000147676
	ENSMUSG00000024479
	Q969L2
	Q8BI08
	NM_052886
	NM_178920
	NP_443118; NP_443118.1
	NP_849251
	Wikidata
View/Edit Human	View/Edit Mouse

Protein MAL2 is a protein that in humans is encoded by the MAL2 gene.

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.