Lormetazepam

Lormetazepam
Clinical data
Trade names	Noctamid, Loramet, others
Other names	Methyllorazepam; Methyl-lorazepam; N-Methyllorazepam; Ro 5-5516
AHFS/Drugs.com	International Drug Names
Pregnancy; category	D;
Routes of; administration	Oral, intravenous
Drug class	Benzodiazepine
ATC code	N05CD06 (WHO) ;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Prescription only (Anlage III for higher doses); US: Schedule IV;
Pharmacokinetic data
Bioavailability	80%
Metabolism	Hepatic
Elimination half-life	10–12 hours
Excretion	Renal
Identifiers
	IUPAC name (RS)-7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one;
CAS Number	848-75-9 ;
PubChem CID	13314;
IUPHAR/BPS	7553;
DrugBank	DB13872 ;
ChemSpider	12750 ;
UNII	GU56C842ZA;
KEGG	D01657 ;
ChEBI	CHEBI:52993 ;
ChEMBL	ChEMBL22097 ;
CompTox Dashboard (EPA)	DTXSID40862442 ;
ECHA InfoCard	100.011.546
Chemical and physical data
Formula	C16H12Cl2N2O2
Molar mass	335.18 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClC1=CC=CC=C1C2=NC(C(N(C)C3=C2C=C(C=C3)Cl)=O)O;
	InChI InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3 ; Key:FJIKWRGCXUCUIG-UHFFFAOYSA-N ;
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Lormetazepam, sold under the brand name Noctamid among others, is a drug which is a short to intermediate acting 3-hydroxy benzodiazepine derivative and temazepam analogue. It possesses hypnotic, anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties.

It was patented in 1961 and came into medical use in 1980. Lormetazepam is not approved for sale in the United States or Canada. It is licensed in the UK as 0.5 and 1 mg tablets for short-term treatment (2–4 weeks) of moderately severe insomnia. It is licensed in the Netherlands as 1 and 2 mg tablets, under the brand names Loramet and Noctamid and as generic, available from several manufacturers. It is sold in Poland as Noctofer. It is also sold in France as generic as 1 and 2mg tablets, with a maximum prescription duration of 4 weeks. A Dutch analysis stated that lormetazepam could be suitable to be included in drug prescribing formularies, although zolpidem, zopiclone, and temazepam appear better.