Atropine/diphenoxylate
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|---|---|
| Diphenoxylate | Mu opiate receptor agonist |
| Atropine | Muscarinic acetylcholine receptors antagonist |
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| Trade names | Lomotil |
| AHFS/Drugs.com | Professional Drug Facts |
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| Routes of administration | By mouth |
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Diphenoxylate/atropine, also known as co-phenotrope and sold under the brand name Lomotil among others, is used to treat diarrhea. It is a fixed-dose combination of the medications diphenoxylate, as the hydrochloride, an antidiarrheal; and atropine, as the sulfate, an anticholinergic. It is taken by mouth. Onset is typically within an hour.
Side effects may include abdominal pain, angioedema, glaucoma, heart problems, feeling tired, dry mouth, and trouble seeing. It is unclear if use in pregnancy is safe and use when breastfeeding may result in side effects in the baby. It works by decreasing contractions of the bowel.
The combination was approved for medical use in the United States in 1960. It is available as a generic medication. In 2022, it was the 284th most commonly prescribed medication in the United States, with more than 600,000 prescriptions. The combination is in Schedule V in the United States.