Langerin

CD207
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3C22, 3KQG, 3P5D, 3P5E, 3P5F, 3P5G, 3P5H, 3P5I, 3P7F, 3P7G, 3P7H, 4AK8, 4N32, 4N33, 4N34, 4N35, 4N36, 4N37, 4N38
Identifiers
Aliases	CD207, CLEC4K, CD207 molecule
External IDs	OMIM: 604862; MGI: 2180021; HomoloGene: 9252; GeneCards: CD207; OMA:CD207 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	70,835,816 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,654,839 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of hip; ; skin of abdomen; ; skin of arm; ; vulva; ; nipple; ; epithelium of esophagus; ; oral cavity; ; gums; ; gingival epithelium;
	Top expressed in
	skin of external ear; ; thymus; ; lip; ; skin of abdomen; ; liver; ; spleen; ; left lobe of liver; ; right lung lobe; ; skin of back; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	mannose binding; carbohydrate binding; protein binding;
Cellular component	integral component of membrane; clathrin-coated endocytic vesicle membrane; plasma membrane; endocytic vesicle; early endosome membrane; membrane;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; defense response to virus; receptor-mediated endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	50489
	246278
	ENSG00000116031
	ENSMUSG00000034783
	Q9UJ71
	Q8VBX4
	NM_015717
	NM_144943
	NP_056532
	NP_659192
	Wikidata
View/Edit Human	View/Edit Mouse

Langerin (CD207) is a type II transmembrane protein which is encoded by the CD207 gene in humans. It was discovered by scientists Sem Saeland and Jenny Valladeau as a main part of Birbeck granules. Langerin is C-type lectin receptor on Langerhans cells (LCs) and in mice also on dermal interstitial CD103+ dendritic cells (DC) and on resident CD8+ DC in lymph nodes.