LGMN

LGMN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4N6N, 4N6O, 4FGU, 4AWB, 4AWA, 4AW9
Identifiers
Aliases	LGMN, AEP, LGMN1, PRSC1, legumain
External IDs	OMIM: 602620; MGI: 1330838; HomoloGene: 38075; GeneCards: LGMN; OMA:LGMN - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	92,748,679 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	102,406,072 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; gallbladder; ; synovial membrane; ; right coronary artery; ; left lobe of thyroid gland; ; placenta; ; rectum; ; right lobe of thyroid gland; ; spleen; ; oocyte;
	Top expressed in
	stroma of bone marrow; ; yolk sac; ; right kidney; ; human kidney; ; neural layer of retina; ; calvaria; ; decidua; ; saccule; ; proximal tubule; ; ankle joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; peptidase activity; hydrolase activity; cysteine-type endopeptidase activity; tau protein binding;
Cellular component	late endosome; apical part of cell; lysosomal lumen; lysosome; extracellular exosome; endolysosome lumen; extracellular region; cytoplasm; perinuclear region of cytoplasm;
Biological process	negative regulation of neuron apoptotic process; negative regulation of ERBB signaling pathway; renal system process; antigen processing and presentation of exogenous peptide antigen via MHC class II; vitamin D metabolic process; negative regulation of multicellular organism growth; vacuolar protein processing; receptor catabolic process; proteolysis; toll-like receptor signaling pathway; proteolysis involved in cellular protein catabolic process; response to acidic pH; memory; positive regulation of cell population proliferation; associative learning; negative regulation of gene expression; cellular response to hepatocyte growth factor stimulus; positive regulation of mitotic cell cycle; cellular response to calcium ion; positive regulation of monocyte chemotaxis; dendritic spine organization; activation of cysteine-type endopeptidase activity; self proteolysis; positive regulation of long-term synaptic potentiation; cellular response to amyloid-beta; positive regulation of endothelial cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	5641
	19141
	ENSG00000100600
	ENSMUSG00000021190
	Q99538
	O89017
	NM_001008530; NM_005606; NM_001363696; NM_001363699
	NM_011175; NM_001378875
	NP_001008530; NP_005597; NP_001350625; NP_001350628
	NP_035305; NP_001365804
	Wikidata
View/Edit Human	View/Edit Mouse

Legumain is a protein that in humans is encoded by the LGMN gene.

This gene encodes a cysteine protease, legumain, that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.